La codeina viene utilizzata for every contrastare il dolore di intensità lieve o moderata. In combinazione con altri farmaci viene inoltre impiegato for every calmare la tosse.
Small children with obstructive rest apnea who are dealt with with codeine for publish-tonsillectomy and/or adenoidectomy pain might be particularly delicate to its respiratory depressant influence; as a result of chance of life-threatening respiratory melancholy and Demise: codeine is contraindicated in all kids youthful than twelve a long time of age; it is also contraindicated for publish-operative administration in pediatric patients youthful than eighteen yrs of age subsequent tonsillectomy and/or adenoidectomy
As a slumber aid, Makatussin Comp. must be taken roughly 30 minutes in advance of bedtime. Take each dose that has a total glass of h2o.
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amiodarone will increase the amount or impact here of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Caution/Keep track of. Prevents Makatussin Syrop conversion of codeine to its Lively metabolite morphine.
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buprenorphine subdermal implant and codeine equally enhance sedation. Stay clear of or Use Alternate Drug. Restrict use to patients for whom option procedure alternatives are insufficient
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If you are making use of sustained-release tablets or capsules, swallow the medication entire. Never crush, chew, or break the tablets or capsules. Doing this can wipe out the lengthy motion more info from the drug and may improve Unintended effects.
Gli oppioidi agiscono legandosi agli specifici recettori (recettori degli oppioidi), che si trovano principalmente nel sistema nervoso centrale e periferico e nel tratto gastrointestinale.